INTRODUCTION:

Andrew R. Pachner

Anti-IFNß antibodies in IFNß-treated MS patients: Summary
Neurology 2003 61: S1-5. [Full Text]  

ARTICLES:

Section I: Immunity to interferons and other biologicals:

Klaus Bendtzen

Anti-IFN BAb and NAb antibodies: A minireview
Neurology 2003 61: S6-10. [Full Text] [Figures Only]  

Huub Schellekens

The immunogenicity of biopharmaceuticals
Neurology 2003 61: S11-12. [Full Text] [Figures Only]  

Gavin Giovannoni

Strategies to treat and prevent the development of neutralizing anti-interferon-ß antibodies
Neurology 2003 61: S13-17. [Abstract] [Full Text] [Figures Only]  

Section II: Assays of antibodies to IFNβ:

Andrew R. Pachner, Joel Oger, and Jacqueline Palace

The measurement of antibodies binding to IFNß in MS patients treated with IFNß
Neurology 2003 61: S18-20. [Full Text] [Figures Only]  

Sidney E. Grossberg

Perspectives on the neutralization of interferons by antibody
Neurology 2003 61: S21-23. [Abstract] [Full Text] [Figures Only]  

Section III: MxA assays as measurements of IFN:

Andrew R. Pachner, Antonio Bertolotto, and Florian Deisenhammer

Measurement of MxA mRNA or protein as a biomarker of IFNß bioactivity: Detection of antibody-mediated decreased bioactivity (ADB)
Neurology 2003 61: S24-26. [Abstract] [Full Text] [Figures Only]  

Section IV: Experience of MS centers with anti-IFNβ antibodies:

Per Soelberg Sorensen

Antibodies to IFN-beta: The Danish National IFN-beta Project
Neurology 2003 61: S27-28. [Full Text] [Figures Only]  

Marcelo Kremenchutzky

Long-term evolution of anti-INFß antibodies in IFNß-treated MS patients: The London, Canada, MS Clinic experience
Neurology 2003 61: S29-30. [Full Text]  

Richard A. Rudick

Biologic impact of interferon antibodies, and complexities in assessing their clinical significance
Neurology 2003 61: S31-34. [Abstract] [Full Text] [Figures Only]  

A. John Petkau

Statistical approaches to assessing the effects of neutralizing antibodies: IFNß-1b in the pivotal trial of relapsing-remitting multiple sclerosis
Neurology 2003 61: S35-37. [Abstract] [Full Text] [Figures Only]  

Gary Cutter

Statistical issues in neutralizing antibodies
Neurology 2003 61: S38-39. [Full Text]  

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