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Published online before print August 23, 2006, doi:10.1212/01.wnl.0000237038.55627.5b)
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Received January 17, 2006
Accepted June 19, 2006

Anatomical correlates of early mutism in progressive nonfluent aphasia

M. L. Gorno-Tempini MD, PhD*, J. M. Ogar MS, S. M. Brambati PhD, P. Wang MD, J. H. Jeong MD, K. P. Rankin PhD, N. F. Dronkers PhD, and B. L. Miller MD

From the Department of Neurology, University of California at San Francisco.


* To whom correspondence should be addressed. E-mail: marilu{at}memory.ucsf.edu.

Abstract-- Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume loss was more prominent in the pars opercularis and extended into the left basal ganglia. Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA.




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