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Invited Article: Changing concepts in Parkinson disease

Moving beyond the Decade of the Brain

From Toronto Western Hospital, University Health Network and University of Toronto, Ontario, Canada.

Address correspondence and reprint requests to Dr. Anthony Lang, Movement Disorders Centre, Toronto Western Hospital 7McL, 399 Bathurst Street, Toronto, ON Canada M5T 2S8 lang{at}uhnres.utoronto.ca

Recent years have seen major changes in our understanding of Parkinson disease (PD), challenging conventional wisdom, much of which was established during the Decade of the Brain. In this article, we highlight important changes in our understanding of PD in six general categories: definition, etiology, pathology, pathogenesis, clinical features, and therapeutics.

Abbreviations: PD = Parkinson disease.

Disclosure: The authors report no disclosures.

Presented in part at the 59th annual meeting of the American Academy of Neurology, Boston, MA, April 28–May 5, 2007.

Received November 7, 2007. Accepted in final form February 5, 2008.

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