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Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings

From the Departments of Neurology and Pediatrics (E.W., D.K.L., A.G., A.C., G.C., P.K.), Biostatistics (S.W.), Neuroradiology (P.R.), and Neurosurgery (W.E.B.), Cleveland Clinic Children’s Hospital, OH.

Address correspondence and reprint requests to Dr. E. Wyllie, Center for Pediatric Neurology, Cleveland Clinic Children’s Hospital, 9500 Euclid Ave., Cleveland, OH 44195 wylliee{at}ccf.org

Objective: To understand the role of epilepsy surgery in children with generalized or bilateral findings on preoperative scalp EEG.

Methods: From our pediatric epilepsy surgery series, we identified 50 patients in whom 30 to 100% of preoperative epileptiform discharges (ictal, interictal, or both) were generalized or contralateral to the side of surgery.

Results: All patients had severe refractory epilepsy and an epileptogenic lesion on brain MRI. Ninety percent of the lesions were congenital, perinatal, or acquired during infancy, predominantly malformations of cortical development (44%) or cystic encephalomalacia (40%). Age at surgery was 0.2 to 24 (median 7.7) years. Surgeries were hemispherectomy (64%) or lobar or multilobar resection. At last follow-up (median 24.0 months), 72% of patients were seizure-free, 16% had marked improvement with only brief episodes of staring or tonic stiffening, and 12% were not improved. The rate of seizure-free outcome was not significantly associated with age at seizure onset or surgery, presence of hemiparesis or focal clinical features during seizures, type of lesion, or surgery type. Postoperative seizure-free rate did not differ from that in a comparison group of similar patients who matched the study group except for their high percentage (70 to 100%) of ipsilateral ictal and interictal epileptiform discharges on preoperative EEG.

Conclusions: Epilepsy surgery may be successful for selected children and adolescents with a congenital or early-acquired brain lesion, despite abundant generalized or bilateral epileptiform discharges on EEG. The diffuse EEG expression may be due to an interaction between the early lesion and the developing brain.

Disclosure: The authors report no conflicts of interest.

Received October 20, 2007. Accepted in final form February 27, 2007.

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