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Comparison of elective stenting of severe vs moderate intracranial atherosclerotic stenosis

From the Neurovascular Angioplasty Team, Department of Neurology (K.H.D.), Interventional Neuroradiology (W.J.J., B.D., M.J.), and Neuroradiology (X.T.X., Q.H.W., N.M.), Beijing Tiantan Hospital, The Capital University of Medical Sciences, No. 6 Tiantan Xili, Beijing, China.

Address correspondence and reprint requests to Dr. Wei-Jian Jiang, Department of Neurology and Interventional Neuroradiology, Beijing Tiantan Hospital, The Capital University of Medical Sciences, No. 6 Tiantan Xili, Beijing 100050, China; e-mail: cjr.jiangweijian{at}vip.163.com

Objective: To test whether symptomatic severe intracranial atherosclerotic stenosis was associated with a higher subsequent stroke risk than moderate stenosis after elective angioplasty with a balloon-expandable stent and to explore which factors were associated with the subsequent stroke.

Methods: Between September 2001 and June 2005, there were 220 symptomatic intracranial atherosclerotic stenoses in 213 patients undergoing elective stenting at our institute. Of these stenoses, 126 in 121 patients were 70% severe stenoses, and 94 in 92 patients were 50% to 69% moderate stenoses. Primary endpoints included lesion-related ischemic stroke, and symptomatic brain or subarachnoid hemorrhage.

Results: Ten primary endpoint events occurred in the severe stenosis group (six within 30 days and four in mean follow-up of 26.0 months after 30 days), and seven occurred in the moderate stenosis group (four within 30 days and three in mean follow-up of 27.6 months after 30 days). There was no significant difference in cumulative probability of primary endpoints between the severe (7.2% at 1 year and 8.2% at 2 years) and moderate (5.3% at 1 year and 8.3% at 2 years) stenosis groups. No single factor was found to be associated with primary endpoints in the moderate stenosis group. Multivariable analysis revealed that stent failure was the only predictor of primary endpoints in the severe stenosis group (hazard ratio 5.31, 95% CI 1.35 to 20.91).

Conclusion: Symptomatic severe intracranial atherosclerotic stenosis did not present a higher subsequent stroke risk than moderate stenosis after elective angioplasty with a balloon-expandable stent. Patients with severe stenosis may benefit from successful stent placement, and randomized trials are necessary to demonstrate this possible benefit.

Supported by The Ministry of Health of The People’s Republic of China (2004BA714B-7).

Disclosure: The authors report no conflicts of interest.

Received June 28, 2006. Accepted in final form October 13, 2006.

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