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Activities of daily living in frontotemporal dementia and Alzheimer disease

From the University of Cambridge Department of Clinical Neurosciences (E.M., C.M.K., K.D., J.M., A.G., J.R.H.), Addenbrooke's Hospital, and MRC Cognition and Brain Sciences Unit (E.M., J.R.H.), Cambridge, UK.

Address correspondence and reprint requests to Prof Hodges, MRC-CBU, 15 Chaucer Rd., Cambridge, CB2 7EF UK john.hodges{at}mrc-cbu.cam.ac.uk

Objective: To evaluate activities of daily living (ADLs) in three clinical variants of frontotemporal dementia and the relationship to cognitive dysfunction.

Methods: Fifty-nine patients and caregivers participated in this cross-sectional study: behavioral variant frontotemporal dementia (bv-FTD, n = 15), progressive nonfluent aphasia (PNFA, n = 10), semantic dementia (n = 15), and Alzheimer disease (AD, n = 19). Caregivers were interviewed with the Disability Assessment for Dementia (DAD) to provide two outcome measures about ADLs: basic and instrumental ADLs (BADLs, IADL). In addition, patients were rated on the Clinical Dementia Rating Scale (CDR), and performance on cognitive measures (Addenbrooke's Cognitive Examination Revised [ACE-R]) was assessed.

Results: On the DAD, the bv-FTD group was most affected (56% of normal), whereas PNFA and semantic dementia patients were least impaired (83% and 85%); AD was intermediate (76%). The opposite pattern was seen on the ACE-R, where PNFA and semantic dementia groups were most affected, and bv-FTD showed least impairment; AD was again intermediate. Scores on the DAD did not correlate with cognitive measures, CDR, or disease duration. We further analyzed which aspect of ADLs was most affected, and a unique pattern of deficits emerged for the bv-FTD group (initiation affected > planning > execution for BADLs).

Conclusion: Frontotemporal dementia has a devastating effect on activities of daily living, which is of considerable importance to caregivers and not captured by bedside cognitive tests.

J.R.H. is funded by an MRC program grant, and C.M.K. is supported by the Wellcome Trust (grant no. 073580).

Disclosure: The authors report no conflicts of interest.

Received July 28, 2006. Accepted in final form February 6, 2007.

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