Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lerner, A.
Right arrow Articles by Hallett, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lerner, A.
Right arrow Articles by Hallett, M.
Related Collections
Right arrow All Imaging
Right arrow Tourette syndrome
Right arrow Tics
Right arrow Cerebellum
NEUROLOGY 2007;68:1979-1987
© 2007 American Academy of Neurology

Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome

A. Lerner, MD, PhD, A. Bagic, MD, E. A. Boudreau, MD, PhD, T. Hanakawa, MD, PhD, F. Pagan, MD, Z. Mari, MD, W. Bara-Jimenez, MD, M. Aksu, MD, G. Garraux, MD, J. M. Simmons, MD, PhD, S. Sato, MD, D. L. Murphy, MD and M. Hallett, MD

From the Molecular Imaging Branch (A.L.), Laboratory of Neuropsychology (J.M.S.), and Laboratory of Clinical Science (D.L.M.), National Institute of Mental Health, and EEG Section (A.B., E.A.B., S.S.) and Human Motor Control Section (T.H., F.P., Z.M., W.B.-J., M.A., G.G., M.H.), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.

Address correspondence and reprint requests to Dr. Alicja Lerner, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 31 Center Drive MSC 2035, Bldg. 31, Room B2-B34, Bethesda, MD 20892-2035 lernera{at}mail.nih.gov

Objective: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline.

Methods: We used [15O]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2.

Results: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release.

Conclusion: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.

Supplemental data at www.neurology.org

Supported by the Intramural Research Programs of the National Institute of Neurological Disorders and Stroke and National Institute of Mental Health, NIH.

Disclosure: The authors report no conflicts of interest.

Received July 21, 2006. Accepted in final form February 5, 2007.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by AAN Enterprises, Inc.