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NEUROLOGY 2007;68:146-149
© 2007 American Academy of Neurology

Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke

B. W. Yoon, MD, PhD, H. J. Bae, MD, PhD, K. S. Hong, MD, PhD, S. M. Lee, PhD, B. J. Park, MD, PhD, K. H. Yu, MD, PhD, M. K. Han, MD, PhD, Y. S. Lee, MD, PhD, D. K. Chung, MD, PhD, J. M. Park, MD, PhD, S. W. Jeong, MD, PhD, B. C. Lee, MD, PhD, K. H. Cho, MD, PhD, J. S. Kim, MD, PhD, S. H. Lee, MD, PhD, K. M. Yoo, MD, PhD for the Acute Brain Bleeding Analysis (ABBA) Study Investigators*

From the Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine (B.W.Y., S.H.L.); Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine (H.J.B., M.K.H., J.S.K.); Department of Neurology, Ilsan Paik University Hospital, Inje University (K.S.H.); Department of Preventive Medicine, Seoul National University College of Medicine (S.M.L., B.J.P.); Department of Neurology, Hallym University College of Medicine (K.H.Y., B.C.L.); Department of Neurology, Seoul National University Boramae Hospital, Seoul National University College of Medicine (Y.S.L.); Department of Neurology, Kyungpook National University Hospital (D.K.C.); Department of Neurology, Eulji General Hospital, Eulji University School of Medicine (J.M.P.); Department of Neurology, Dongguk University International Hospital, Dongguk University College of Medicine (S.W.J.); Department of Neurology, Chonnam National University Hospital, Chonnam National University College of Medicine (K.H.C.); and Department of Neurology, Kosin Medical College Hospital (K.M.Y.), Republic of Korea.

Address correspondence and reprint requests to Dr. Byung-Woo Yoon, Department of Neurology, Seoul National University Hospital, 28 Yongon-dong, Jongno-gu, Seoul, 110-744, Republic of Korea; e-mail: bwyoon{at}snu.ac.kr

In this study, we sought to elucidate whether phenylpropanolamine (PPA) in cold remedies (small and divided doses) increases the risk of hemorrhagic stroke (HS). PPA exposure significantly increased the risk, and the risk was much higher in women. In women, linear trends were also found in recency, duration, and dosage of PPA exposure. PPA contained in cold remedies increases the risk of HS, particularly in women.

*See appendix for a complete list of ABBA Study Investigators.

Supported by the Korean Food and Drug Association.

Disclosure: The authors report no conflicts of interest.

Received March 20, 2006. Accepted in final form September 27, 2006.


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Correspondence:

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Phenylpropanolamine contained in cold remedies and risk of hemorrhagic stroke
James N. Domingue
Neurology Online, 1 Apr 2007 [Full text]
Reply from the Authors
Byung-Woo Yoon, MD, PhD, et al.
Neurology Online, 1 Apr 2007 [Full text]

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