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Challenges in the classification of pediatric multiple sclerosis and future directions

From the State University of New York at Stony Brook (A.B.); Massachusetts General Hospital for Children (T.C.), Brigham & Women’s Hospital, Harvard Medical, Boston; Service de Neurologie A (C.R.), Hôpital Neurologique, Lyon, France; and Multiple Sclerosis Center at UCSF (E.W.), San Francisco, CA.

Address correspondence and reprint requests to Dr. Anita Belman, Department of Neurology, School of Medicine HSC 12-020, Stony Brook University Medical Center, Stony Brook, NY 11794; e-mail: abelman{at}notes.cc.sunysb.edu

To improve care for children with multiple sclerosis (MS) and to advance understanding of the underlying biologic mechanisms through collaborative research studies, criteria for case definitions of pediatric MS and related CNS demyelinating disorders were proposed by the International Pediatric MS Study Group. Issues raised during development of these definitions and rationale behind criteria proposed are summarized in this article, as are potential international multicenter research studies that would be facilitated by the application of a uniform set of definitions.

*Members of the International Pediatric MS Study Group are listed in the Appendix.

Disclosure: The authors report no conflicts of interest