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 Volume 68, Number 13, March 27, 2007
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NEUROLOGY 2007;68:991-995
© 2007 American Academy of Neurology
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Advances in understanding ventromedial prefrontal function

The accountant joins the executive

Lesley K. Fellows, MDCM, DPhil

From the Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.

Address correspondence and reprint requests to Dr Fellows, Montreal Neurological Institute, 3801 University St., Rm. 276, Montreal, Quebec, Canada H3A 2B4; e-mail: lesley.fellows{at}mcgill.ca

Studies of the brain basis of decision-making and economic behavior are providing a new perspective on the organization and functions of human prefrontal cortex. This line of inquiry has focused particularly on the ventral and medial portions of prefrontal cortex, arguably the most enigmatic regions of the "enigmatic frontal lobes." This review highlights recent advances in the cognitive neuroscience of decision making and neuroeconomics and discusses how these findings can inform clinical thinking about frontal lobe dysfunction.

Supported by a Canadian Institutes of Health Research Clinician–Scientist Award and by operating grants from CIHR (MOP-77583, RAN-79911) and the Fonds de recherche en santé de Québec.

Disclosure: The author reports no conflicts of interest.

Received June 22, 2006. Accepted in final form November 21, 2006.




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