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Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation

A.S.C.-P. and K.A.V. are from the Department of Neurology, Massachusetts General Hospital and Brigham and Women’s Hospital, Boston, MAS. is from the Department of Neurology, Brigham and Women’s Hospital, Boston, MA. M.H.C. is from the Department of Cardiology, Children’s Hospital, Boston, MA, and the Department of Medicine, Divisions of Cardiology and Women’s Health, Brigham and Women’s Hospital, Boston, MA.

Address correspondence and reprint requests to Dr. Alice S. Chen-Plotkin, Department of Neurology, Brigham and Women’s Hospital, 75 Francis St., Boston, MA 02115; e-mail: aschen{at}partners.org

Stem cell transplants are established therapy for hematologic and solid tumor malignancies. Known neurological complications of stem cell transplantation include CNS infection, seizures, strokes, metabolic encephalopathy, and hemorrhage. We report two cases of autologous stem cell transplantation complicated by cerebral infarction and myocardial injury. We postulate that the cryopreservative dimethyl sulfoxide may be responsible.

*These authors contributed equally to this work.

Disclosure: The authors report no conflicts of interest.

Received May 17, 2006. Accepted in final form November 13, 2006.

This article has been cited by other articles:

				H. Savolainen, A. S. Chen-Plotkin, K. A. Vossel, M. A. Samuels, and M. H. Chen ENCEPHALOPATHY, STROKE, AND MYOCARDIAL INFARCTION WITH DMSO USE IN STEM CELL TRANSPLANTATION Neurology, July 31, 2007; 69(5): 494 - 495. [Full Text] [PDF]

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