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CSF opening pressure: Reference interval and the effect of body mass index

From the Division of Clinical Neurosciences, University of Edinburgh, UK (W.W., R.A.-S., C.P.W., M.Z.); and The Canberra Hospital and the Australian National University, Canberra, Australia (C.J.L.).

Address correspondence and reprint requests to Dr. William Whiteley, Bramwell Dott Building, Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK; e-mail: wwhitele{at}staffmail.ed.ac.uk

We prospectively recorded CSF opening pressure in 242 adults who had a lumbar puncture with concomitant measurement of weight and height. The 95% reference interval for lumbar CSF opening pressure was 10 to 25 cm CSF. Body mass index had a small but clinically insignificant influence on CSF opening pressure.

Disclosure: The authors report no conflicts of interest.

Authors’ contributions: C.J.L. had the original idea for the study. W.W., R.A.S., C.P.W., and C.L. conceived and planned the study design, data collection, and analysis. W.W., R.A.S., and M.Z. conducted the study. Every author contributed to interpretation of data. W.W. and R.A.S. drafted the article, and every author revised it critically for important intellectual content. All authors gave final approval of the version to be published. C.P.W. is responsible for the overall content as guarantor.

Received May 4, 2006. Accepted in final form July 21, 2006.

This article has been cited by other articles:

				F. Bono, A. Quattrone, W. N. Whiteley, R. A.-S. Salman, C. Lueck, and C. Warlow CSF OPENING PRESSURE: REFERENCE INTERVAL AND THE EFFECT OF BODY MASS INDEX Neurology, April 24, 2007; 68(17): 1439 - 1440. [Full Text] [PDF]

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