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NEUROLOGY 2006;67:1671-1673
© 2006 American Academy of Neurology
Brief Communications

What happens now? Ongoing outcome after post-temporal lobectomy seizure recurrence

Anne M. McIntosh, PhD and Samuel F. Berkovic, MD

From the Epilepsy Research Centre (A.M.M., S.F.B.), School of Nursing (A.M.M.), and Department of Medicine (Neurology) (A.M.M., S.F.B.), University of Melbourne; and Department of Neurology (S.F.B.), Austin Health, Melbourne, Victoria, Australia.

Address correspondence and reprint requests to Dr. Anne McIntosh, Epilepsy Research Centre (Repatriation Campus), Austin Health, Melbourne, Victoria 3081, Australia; e-mail: a.mcintosh{at}unimelb.edu.au

We studied outcome subsequent to the initial post-temporal lobectomy seizure recurrence (n = 202) or remission. Two years after recurrence, there was 74% (95% CI 67% to 79%) probability of further seizures. Two years after a 2-year seizure remission, there was 68% (95% CI 52% to 79%) probability of remaining seizure-free (n = 50). Remission after seizures had a significantly poorer outcome than an equivalent period of complete seizure freedom after surgery. Implications for outcome classification are discussed.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the November 14 issue to find the title link for this article.

This research was supported in part by the Australian National Health and Medical Research Council, the Austin Hospital Medical Research Foundation, and the Epilepsy Association, Australia.

Disclosure: The authors report no conflicts of interest.

Received December 19, 2005. Accepted in final form July 7, 2006.






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