Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Data Supplement
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chana, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chana, G.
Related Collections
Right arrow HIV
Right arrow All Neuropsychology/Behavior
Right arrow All Cognitive Disorders/Dementia
Right arrow All Toxicology
NEUROLOGY 2006;67:1486-1489
© 2006 American Academy of Neurology
Brief Communications

Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users

G. Chana, PhD, I. P. Everall, MD, PhD, L. Crews, BS, D. Langford, PhD, A. Adame, I. Grant, MD, M. Cherner, PhD, D. Lazzaretto, PhD, R. Heaton, PhD, R. Ellis, MD, E. Masliah, MD and the HNRC Group*

From the Departments of Neurosciences (L.C., A.A., R.E., E.M.), Pathology (D.L., E.M.), and Psychiatry (G.C., I.P.E., I.G., M.C., D.L., R.H.) and the HIV Neurobehavioral Research Center, University of California, San Diego/La Jolla, CA; and Veterans Affairs Healthcare System (I.G.), La Jolla, CA.

Address correspondence and reprint requests to Dr. Eliezer Masliah, Department of Neurosciences, University of California San Diego, La Jolla, CA 92093-0624; e-mail: emasliah{at}ucsd.edu

The cellular basis for cognitive deficits in HIV+ patients with and without a history of methamphetamine (METH) use is unclear. We found that HIV+ METH users had more severe loss of interneurons that was associated with cognitive impairment. Compared with other markers, loss of calbindin and parvalbumin interneurons in the frontal cortex was the most significant correlate to memory deficits, suggesting a role in neurobehavioral alterations of HIV+ METH users.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the October 24 issue to find the title link for this article.

*See appendix for a list of Group members.

This work was supported by NIH Grants MH59745, MH45294, MH58164, and DA12065, and an HNRC pilot project award. The HIV Neurobehavioral Research Center is supported by Center award MH 62512 from the National Institute of Mental Health.

Disclosure: The authors report no conflicts of interest.

The views expressed in this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department of Defense, nor the United States Government.

Received November 28, 2005. Accepted in final form June 22, 2006.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by AAN Enterprises, Inc.