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NEUROLOGY 2006;67:1470-1472
© 2006 American Academy of Neurology
Brief Communications

CSF tau protein: A new prognostic marker for Guillain-Barré syndrome

K. Jin, MD, A. Takeda, MD, PhD, Y. Shiga, MD, PhD, S. Sato, MD, PhD, A. Ohnuma, MD, PhD, H. Nomura, MD, PhD, H. Arai, MD, PhD, S. Kusunoki, MD, PhD, M. Ikeda, PhD and Y. Itoyama, MD, PhD

From the Department of Neurology (K.J., S.S., A.O., H.N.), Kohnan Hospital; Department of Neurology (K.J.), Iwate National Hospital; Departments of Neurology (A.T., Y.S., Y.I.) and Geriatric and Complementary Medicine (H.A.), Center for Asian Traditional Medicine Research, Tohoku University Graduate School of Medicine; Department of Neurology (S.K.), Kinki University School of Medicine; and Institute of Industrial Ecological Sciences (M.I.), University of Occupational and Environmental Health, Japan.

Address correspondence and reprint requests to Dr. Takeda, Department of Neurology, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan; e-mail: atakeda{at}em.neurol.med.tohoku.ac.jp

We measured the CSF tau protein levels in 26 patients with Guillain-Barré syndrome. The levels of the poor outcome group (Hughes grade at 6 months was between II and VI, n = 6) were higher than those of the good outcome group (0 or I, n = 20) (p < 0.0005). The higher levels of CSF tau may reflect axonal degeneration and could predict a poor clinical outcome in Guillain-Barré syndrome.

Disclosure: The authors report no conflicts of interest.

Received January 20, 2006. Accepted in final form June 27, 2006.




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A. Asbury, A. Takeda, K. Jin, S. Kusunoki, and Y. Itoyama
CSF TAU PROTEIN: A NEW PROGNOSTIC MARKER FOR GUILLAIN-BARRE SYNDROME
Neurology, April 24, 2007; 68(17): 1438 - 1439.
[Full Text] [PDF]

Correspondence:

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CSF tau protein: A new prognostic marker for Guillain-Barre syndrome
Arthur Asbury, MD
Neurology Online, 4 Dec 2006 [Full text]
Reply from the Authors
Atsushi Takeda, et al.
Neurology Online, 4 Dec 2006 [Full text]

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