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NEUROLOGY 2006;67:1090-1093
© 2006 American Academy of Neurology
Brief Communications

Pathologic and physiologic function in the subcortical band of double cortex

R. S. Briellmann, MD, T. Little, MHSc, A. S. Harvey, MD, D. F. Abbott, PhD, R. Jacobs, PhD, A. B. Waites, PhD and G. D. Jackson, MD

From the Brain Research Institute, Heidelberg Heights, Victoria, Australia (R.S.B., T.L., A.S.H., D.F.A., A.B.W., G.D.J.); Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia (R.S.B., D.F.A., A.B.W., G.D.J.); and Departments of Neurology (A.S.H., G.D.J.) and Psychology (R.J.), Royal Children's Hospital, Parkville, Victoria, Australia.

Address correspondence and reprint requests to Dr. Graeme D. Jackson, Brain Research Institute, Neurosciences Building, Austin Health, Heidelberg Heights, Victoria 3081, Australia; e-mail: bri{at}brain.org.au

Double cortex is a neuronal migration disorder, associated with impaired cognitive function and seizures, and characterized by a subcortical band of neurons. Using functional MRI, we assessed the involvement of the subcortical band in language function and with interictal discharges. In both girls assessed, language-associated activation was in typical cortical areas, as well as in parts of the subcortical band. Interictal discharges were associated with deactivation in the subcortical band. This suggests involvement of the subcortical neurons in physiologic and pathologic functions.

Neurosciences Victoria, the National Health and Medical Research Council, and the Brain Imaging Research Foundation, Australia, provided financial support.

Disclosure: The authors report no conflicts of interest.

Received August 23, 2005. Accepted in final form May 23, 2006.




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[Abstract] [Full Text] [PDF]


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