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Published online before print May 17, 2006, doi:10.1212/01.wnl.0000228862.76269.62)
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NEUROLOGY 2006;67:676-678
© 2006 American Academy of Neurology
Brief Communications

Episodic neurologic dysfunction with migraine and reversible imaging findings after radiation

A. Pruitt, MD, J. Dalmau, MD, PhD, J. Detre, MD, A. Alavi, MD and M. R. Rosenfeld, MD, PhD

From the Division of Neuro-oncology (A.P., J.D., J.D., M.R.R.), Department of Neurology, and Division of Nuclear Medicine (A.A.), Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia.

Reported are three adults who developed frequent episodes of a complex neurologic syndrome years after radiation therapy for a brain tumor. MRI and [18F]fluorodeoxyglucose PET performed during the episodes demonstrated dramatic gyral thickening with enhancement and intense hypermetabolism in symptomatic regions that resolved on follow-up studies. EEG during episodes showed only slowing. The differential diagnosis and imaging findings are reviewed.

This article was previously published in electronic format as an Expedited E-Pub on May 17, 2006, at www.neurology.org.

Disclosure: The authors report no conflicts of interest.

Received January 4, 2006. Accepted in final form April 4, 2006.

Address correspondence and reprint request to Dr. M.R. Rosenfeld, Department of Neurology, University of Pennsylvania, 3400 Spruce Street, 3 W. Gates, Philadelphia, PA 19104; e-mail: myrna.rosenfeld{at}uphs.upenn.edu






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