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NEUROLOGY 2006;67:2236-2238
© 2006 American Academy of Neurology
Brief Communications

Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder

T. Miyamoto, MD, PhD, M. Miyamoto, MD, PhD, Y. Inoue, MD, PhD, Y. Usui, MD, K. Suzuki, MD and K. Hirata, MD, PhD

From the Department of Neurology (T.M., M.M., K.S., K.H.), Center of Sleep Medicine (T.M., M.M.), Dokkyo Medical University School of Medicine, Tochigi, Japan; Japan Somnology Center (Y.I.), Neuropsychiatry Research Institute, Tokyo, Japan; Second Department of Internal Medicine (Y.U.), Tokyo Medical University, Tokyo, Japan.

Address correspondence and reprint requests to Dr. Tomoyuki Miyamoto, Dokkyo Medical University School of Medicine; 880 Kitakobayashi, Mibu, Shimotuga, Tochigi 321-0293, Japan; e-mail: miyatomo{at}dokkyomed.ac.jp

Idiopathic REM sleep behavior disorder (RBD) may represent prodromal synucleinopathies. We report markedly reduced cardiac 123I-metaiodobenzylguanidine uptake, consistent with the loss of sympathetic terminals, in idiopathic RBD. We also demonstrate that this reduction is of the same magnitude as that found in patients with Parkinson disease. The results are consistent with the hypothesis that idiopathic RBD in older patients is a forme fruste of Lewy body disease.

Disclosure: The authors report no conflicts of interest

Received June 7, 2006. Accepted in final form September 13, 2006.






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