| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Departments of Neurology (J.E.G., J.C.M.), Anatomy and Neurobiology (J.E.G.), Pathology and Immunology (J.C.M.), and Division of Biostatistics (C.M.R., C.X.), and the Alzheimer's Disease Research Center, Washington University, St. Louis, MO.
Address correspondence and reprint requests to Dr. James E. Galvin, Alzheimer Disease Research Center, Washington University School of Medicine, 4488 Forest Park, Suite 130, St. Louis, MO 63108; e-mail: galvinj{at}neuro.wustl.edu
Objective: To establish the validity, reliability, and discriminative properties of the AD8, a brief informant interview to detect dementia, in a clinic sample.
Methods: We evaluated 255 patient–informant dyads. We compared the number of endorsed AD8 items with an independently derived Clinical Dementia Rating (CDR) and with performance on neuropsychological tests. Construct and concurrent validity, test–retest, interrater and intermodal reliability, and internal consistency of the AD8 were determined. Receiver operator characteristic curves were used to assess the discriminative properties of the AD8.
Results: Concurrent validity was strong with AD8 scores correlating with the CDR (r = 0.75, 95% CI 0.63 to 0.88). Construct validity testing showed strong correlation between AD8 scores, CDR domains, and performance on neuropsychological tests. The Cronbach alpha of the AD8 was 0.84 (95% CI 0.80 to 0.87), suggesting excellent internal consistency. The AD8 demonstrated good intrarater reliability and stability (weighted kappa = 0.67, 95% CI 0.59 to 0.75). Both in-person and phone administration showed equal reliability (weighted kappa = 0.65, 95% CI 0.57 to 0.73). Interrater reliability was very good (Intraclass correlation coefficient = 0.80, 95% CI 0.55 to 0.92). The area under the curve was 0.92 (95% CI 0.88 to 0.95), suggesting excellent discrimination between nondemented individuals and those with cognitive impairment regardless of etiology.
Conclusion: The AD8 is a brief, sensitive measure that validly and reliably differentiates between nondemented and demented individuals. It can be used as a general screening device to detect cognitive change regardless of etiology and with different types of informants.
Supported by grants from the Longer Life Foundation, the National Institute on Aging (K08 AG20764, P01 AG03991, and P50 AG05681), the American Federation for Aging Research, and the Alan A. and Edith L. Wolff Charitable Trust. Dr. Galvin is a recipient of the Paul Beeson Physician Faculty-Scholar in Aging Research Award.
Disclosure: The authors report no conflicts of interest.
Received February 13, 2006. Accepted in final form August 23, 2006.
This article has been cited by other articles:
|
|
 |
|
  W. A. Rocca, J. H. Bower, J. E. Ahlskog, A. Elbaz, B. R. Grossardt, S. K. McDonnell, D. J. Schaid, and D. M. Maraganore Risk of Cognitive Impairment or Dementia in Relatives of Patients With Parkinson Disease Arch Neurol, October 1, 2007; 64(10): 1458 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Rocca, J. H. Bower, D. M. Maraganore, J. E. Ahlskog, B. R. Grossardt, M. de Andrade, and L. J. Melton III Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause Neurology, September 11, 2007; 69(11): 1074 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Galvin, C. M. Roe, and J. C. Morris Evaluation of Cognitive Impairment in Older Adults: Combining Brief Informant and Performance Measures Arch Neurol, May 1, 2007; 64(5): 718 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Galvin, C. M. Roe, M. A. Coats, and J. C. Morris Patient's Rating of Cognitive Ability: Using the AD8, a Brief Informant Interview, as a Self-rating Tool to Detect Dementia Arch Neurol, May 1, 2007; 64(5): 725 - 730. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
