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NEUROLOGY 2006;66:1264-1266
© 2006 American Academy of Neurology
Brief Communications

Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy

R. Lodi, MD, G. Pierangeli, MD, C. Tonon, MD, S. Cevoli, MD, C. Testa, PhD, G. Bivona, MD, F. Magnifico, MD, P. Cortelli, MD, P. Montagna, MD and B. Barbiroli, MD

From the Dipartimento di Medicina Clinica e Biotecnologia Applicata (R.L., C. Tonon., C. Testa, G.B., B.B.), Policlinico S. Orsola-Malpighi, Università di Bologna, Italy; and Dipartimento di Scienze Neurologiche (G.P., S.C., F.M., P.M.), Università di Bologna, Italy.

Address correspondence and reprint requests to Dr. Raffaele Lodi, Dipartimento di Medicina Clinica e Biotecnologia Applicata "D. Campanacci," Università di Bologna, Policlinico S. Orsola, Via Massarenti 9, 40138 Bologna, Italy; e-mail: raffaele.lodi{at}unibo.it

The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.

Disclosure: The authors report no conflicts of interest.

Received July 26, 2005. Accepted in final form January 16, 2006.






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