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NEUROLOGY 2006;66:590-591
© 2006 American Academy of Neurology
Brief Communications

Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures

Daniel Friedman, MD and Jacqueline A. French, MD

From the Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia.

Address correspondence and reprint requests to Dr. Jacqueline A. French, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283; e-mail: frenchj{at}mail.med.upenn.edu

Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the patient had significantly fewer seizures on the day of and after administration. These results suggest a useful treatment strategy for patients with refractory epilepsy who have developed resistance to AEDs.

Disclosure: Dr. French has served as a paid consultant and has received research support (in excess of $10,000) from UCB Pharma. Dr. Friedman reports no conflict of interest.

Received August 3, 2005. Accepted in final form October 31, 2005.






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