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NEUROLOGY 2006;66:433-435
© 2006 American Academy of Neurology
Brief Communications

Vascular and Alzheimer-type pathology in an autopsy study of African-Americans

P. Pytel, MD, E. J. Cochran, MD, G. Bonner, PhD, RN, D. L. Nyenhuis, PhD, C. Thomas, MD and P. B. Gorelick, MD, MPH

From the Department of Pathology (P.P.), the University of Chicago, IL; Department of Pathology (E.J.C.), RUSH University Medical Center, Chicago, IL; Department of Neurology, RUSH University Medical Center, now Department of Neurology and Rehabilitation (G.B., D.L.N., P.B.G.), University of Illinois at Chicago, IL; and Department of Pathology (C.T.), Loyola University Health System, Maywood, IL.

Address correspondence and reprint requests to Dr. Peter Pytel, Department of Pathology, University of Chicago Hospitals, 5841 South Maryland Avenue, M/C 6101, Chicago, IL 60637; e-mail: peter.pytel{at}uchospitals.edu

The authors studied 13 autopsy brains from a larger cohort of 270 African-Americans with a clinical diagnosis of Alzheimer disease (AD), vascular dementia (VaD), or stroke without dementia. Two subjects exhibited changes of pure VaD, 5 had pure AD, and 6 showed a mixture of AD pathology and strokes. Overall, there was good agreement between the pathologic diagnoses and the clinical diagnoses.

Supported by a grant (R01 AG10102) from the U.S. National Institutes of Health–National Institute of Aging, Bethesda, MD.

Disclosure: The authors report no conflicts of interest.

Received June 27, 2005. Accepted in final form October 24, 2005.






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