HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ying, S. H. Articles by Toga, A. W. Search for Related Content PubMed PubMed Citation Articles by Ying, S. H. Articles by Toga, A. W. Related Collections MRI Volumetric MRI Gait disorders/ataxia

Pontine and cerebellar atrophy correlate with clinical disability in SCA2

From Johns Hopkins University School of Medicine (S.H.Y., S.I.C., D.S.Z.), Baltimore, MD; University of California, Los Angeles, School of Medicine (S.L.P., R.W.B., A.W.T.).

Address correspondence and reprint requests to Dr. Sarah H. Ying, Pathology 2-210, 600 North Wolfe Street, Baltimore, MD 21287; e-mail: sying{at}dizzy.med.jhu.edu

Spinocerebellar ataxia type 2 (SCA2) has protean manifestations, and a clinical marker of progression is needed. Although MRI is a promising tool, it is unclear whether the degree of atrophy shown on MRI is correlated with clinical dysfunction. Here the authors used high-resolution volumetric MRI analysis to show that cerebellar and pontine volumes specifically and closely correlate with functional staging scores.

Supported by the Arnold-Chiari Foundation, Robin Zee Fund, NIH grants 5T32DC000023-20, 5T32MH019950-07, 5T32GM007057-28, and EY01849.

Disclosure: The authors report no conflicts of interest.

Received March 21, 2005. Accepted in final form October 27, 2005.