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Hippocampal atrophy in Alzheimer disease: Age matters

From the Department of Neurology (L.A.v.d.P., P.S., W.M.v.d.F.) and Department of Radiology (F.B.), Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands, and Department of Psychiatry (A.H., H.J.G.), University of Leipzig, Germany.

Address correspondence and reprint requests to Dr. Laura A. van de Pol, VU Medical Center, Department of Neurology, Box 7057, 1007 MB Amsterdam, The Netherlands; e-mail: L.vandepol{at}vumc.nl

Hippocampal atrophy is a marker of Alzheimer disease (AD). It remains unclear whether this holds true for younger patients as well. Hippocampal volume was measured on MRI scans of 103 clinically diagnosed AD patients and 73 controls (aged 51 to 85 years). Aging and AD were independently associated with smaller hippocampal volume. Both young and old AD patients have hippocampal atrophy abnormal for age. Age-dependent criteria for hippocampal atrophy, suggestive of AD, are needed.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the January 24 issue to find the title link for this article.

Supported by a grant from Internationale Stichting Alzheimer Onderzoek (no. 02502/028809) and the Interdisciplinary Centre for Clinical Research (IZKF) at the University of Leipzig (01KS9504/1, project C8).

Disclosure: The authors report no conflicts of interest.

Received July 12, 2005. Accepted in final form October 17, 2005.

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