HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Feldman, H. H. Articles by Woodward, M. Search for Related Content PubMed Articles by Feldman, H. H. Articles by Woodward, M.

Neurology supplements are not peer-reviewed. Information contained in Neurology supplements represent the opinions of the authors and are not endorsed by nor do they reflect the views of the American Academy of Neurology, Editor-in-Chief, or Associate Editors of Neurology.

The staging and assessment of moderate to severe Alzheimer disease

From the Division of Neurology (Dr. Feldman), University of British Columbia, Vancouver, BC, Canada, and the Department of Aged Care (Dr. Woodward), Austin Health, Heidelberg, Australia.

Address correspondence to Dr. Howard H. Feldman, Division of Neurology, University of British Columbia Hospital, S192–2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5; e-mail: hfeldman{at}interchange.ubc.ca

Alzheimer disease (AD) and its stages are clinically defined by the patterns of gradual and progressive decline in cognition and in functional ability with accompanying neuropsychiatric symptoms. The moderate to severe AD (MSAD) stages are particularly important both for their prevalence and for the transitions that occur at these stages. In MSAD, cognitive losses accelerate, neuropsychiatric symptoms increase, and functional autonomy is lost. There is increasing burden on caregivers, who report poorer self-rated health, increased depressive symptoms, and more use of psychoactive medications. The neurologic care of MSAD demands both skilled assessment and management. Beyond the cognitive and neurobehavioral symptom complex in MSAD, a range of other issues also emerge, including gait and movement disorders, nutritional problems, and incontinence. This review addresses the symptoms and staging of AD and emphasizes the key management issues.

Publication of this supplement was supported by an unrestricted educational grant from Forest Laboratories, Inc. The sponsor has provided H.H.F. with an honorarium for his participation in this project and honoraria during his career. M.W. has disclosed no financial relationship with the sponsor.

This article has been cited by other articles:

				V. Rondeau, H. Allain, S. Bakchine, P. Bonet, F. Brudon, G. Chauplannaz, B. Dubois, T. Gallarda, J.-P. Lepine, F. Pasquier, et al. General practice-based intervention for suspecting and detecting dementia in France: A cluster randomized controlled trial1 Dementia, November 1, 2008; 7(4): 433 - 450. [Abstract] [PDF]

				Y. Netz, S. Axelrad, and E. Argov Group physical activity for demented older adults feasibility and effectiveness Clinical Rehabilitation, November 1, 2007; 21(11): 977 - 986. [Abstract] [PDF]