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 Volume 65, Number 11, December 13, 2005
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NEUROLOGY 2005;65:1750-1753
© 2005 American Academy of Neurology

Do generalized tonic-clonic seizures in infancy exist?

Christian Korff, MD and Douglas R. Nordli, Jr, MD

From the Epilepsy Center, Children’s Memorial Hospital, Chicago, IL.

Objective: To determine the frequency of generalized tonic-clonic seizures (GTCS) in infants (1 month to 2 years).

Methods: From a total of 2,112 patients monitored in our video-EEG lab from May 2000 through January 2005, 109 distinct seizures in 77 infants were reviewed. Eight events in eight patients were excluded because of video files insufficiently reliable to determine the clinical characteristics with precision. The clinical manifestations and electrographic features of the remaining 101 seizures in 69 infants were retrospectively analyzed.

Results: The authors did not observe a single GTCS. Four patients had icti that resembled GTCS, but careful analysis of these episodes revealed that three of them had a focal onset and that the fourth had a slightly different sequence of events.

Conclusions: Generalized tonic-clonic seizures are rarely, if ever, seen in infants younger than age 2 in a tertiary-care pediatric epilepsy unit. Instead, they more commonly occur in older children, particularly in the well-characterized epilepsy syndromes of childhood and adolescence.

Additional material related to this article can be found on the Neurology Web site. Go to www.neurology.org and scroll down the Table of Contents for the December 13 issue to find the title link for this article.

Supported by a scholarship from the Eugenio Litta Foundation, Vaduz, Liechtenstein (C.M.K.).

Disclosure: The authors report no conflicts of interest.

Received June 7, 2005. Accepted in final form August 16, 2005.

Address correspondence and reprint requests Dr. D.R. Nordli, Jr., Epilepsy Center, Children’s Memorial Hospital, Box 29, 2300 Children’s Plaza, Chicago, IL 60614-3394; e-mail: dnordli{at}childrensmemorial.org


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Neurology 2005 65: 1686-1687. [Full Text]  



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S. Shinnar, D. C. Hesdorffer, D. R. Nordli Jr, J. M. Pellock, C. O'Dell, D. V. Lewis, L. M. Frank, S. L. Moshe, L. G. Epstein, A. Marmarou, et al.
Phenomenology of prolonged febrile seizures: Results of the FEBSTAT study
Neurology, July 15, 2008; 71(3): 170 - 176.
[Abstract] [Full Text] [PDF]


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