Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Correspondence:
View responses
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Assini, A.
Right arrow Articles by Tabaton, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Assini, A.
Right arrow Articles by Tabaton, M.
Related Collections
Right arrow All Neuropsychology/Behavior
Right arrow All Cognitive Disorders/Dementia
Right arrow Alzheimer's disease
Right arrow MCI (mild cognitive impairment)
Right arrowRelated Article
NEUROLOGY 2004;63:828-831
© 2004 American Academy of Neurology

Plasma levels of amyloid ß-protein 42 are increased in women with mild cognitive impairment

A. Assini, MD*, S. Cammarata, MD*, A. Vitali, PhD, M. Colucci, MD, L. Giliberto, MD, R. Borghi, PhD, M. L. Inglese, BSc, S. Volpe, BSc, S. Ratto, MD, F. Dagna-Bricarelli, MD, C. Baldo, PhD, A. Argusti, PhD, P. Odetti, MD, A. Piccini, PhD and M. Tabaton, MD

From the Departments of Neurosciences (Drs. Assini, Vitali, Colucci, Giliberto, Borghi, Piccini, and Tabaton, and M.L. Inglese and S. Volpe) and Internal Medicine (Dr. Odetti), University of Genoa; and the Departments of Neurology (Drs. Cammarata and Ratto) and Human Genetics (Drs. Dagna-Bricarelli, Baldo, and Argusti), Galliera Hospital, Genoa, Italy.

Address correspondence and reprint requests to Dr. Massimo Tabaton, Department of Neurosciences, University of Genoa, Via De Toni 5, 16132 Genoa, Italy; e-mail: mtabaton{at}neurologia.unige.it

Background: Accumulation in the brain of small aggregates of amyloid ß-protein 42 (Aß42) is the major pathogenic event of Alzheimer disease (AD). In familial early-onset AD this event is likely the result of Aß42 overproduction; in the most common sporadic late-onset form of the disease the mechanisms of Aß42 accumulation are unknown.

Methods: To address this issue the authors analyzed plasma levels of Aß42 in 88 elderly patients with amnestic mild cognitive impairment (MCI), chosen as paradigm of preclinical sporadic AD.

Results: The authors found a significant increase of Aß42 plasma levels in women with MCI, in comparison to the affected men and 72 cognitively normal age-matched subjects. The levels were independent of variables in education, apolipoprotein E genotype, cholesterol, and creatinine plasma concentrations, as well as hemoglobin content.

Conclusions: The elevation of Aß42 plasma levels in women with MCI may represent a biologic explanation for the sex-dependent increased incidence of late-onset AD in women identified by epidemiologic studies.

Received January 7, 2004. Accepted in final form April 28, 2004.

*These authors contributed equally to the study.


Related Article

September 14 Highlights
Neurology 2004 63: 766-767. [Full Text] [PDF]



Correspondence:

Read all Correspondence

Plasma levels of amyloid ß-protein 42 are increased in women with mild cognitive impairment
Kurt A. Jellinger, et al.
Neurology Online, 15 Dec 2004 [Full text]

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by AAN Enterprises, Inc.