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Peripheral and central conduction abnormalities in diabetes mellitus

From the Third Department of Medicine (Drs. Suzuki, Ozaki, Tanosaki, and Suda) and Department of Neurology (Drs. Baba and Matsunaga), Hirosaki University School of Medicine, Hirosaki, Japan.

Address correspondence and reprint requests to Dr. Isamu Ozaki, Third Department of Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki 036-8216, Japan; e-mail: isamu{at}cc.hirosaki-u.ac.jp

OBJECTIVES: To investigate peripheral and central somatosensory conduction in patients with diabetes.

METHODS: The authors recorded sensory nerve action potentials and 5-channel somatosensory evoked potentials (SEPs) with noncephalic reference after median nerve stimulation in 55 patients with diabetes and 41 age- and height-matched normal subjects. The authors determined onset or peak latencies of the Erb’s potential (N9) and the spinal N13-P13 and the cortical N20-P20 components, and obtained the central conduction time (CCT) by onset-to-onset and peak-to-peak measurements.

RESULTS: Both onset and peak latencies of all SEP components were prolonged in patients with diabetes. The mean onset CCT in the diabetic group was 6.3 ± 0.5 msec (mean ± SD)—significantly longer than that in the control group (6.1 ± 0.2 msec)—whereas no significant difference was found in the peak CCT. The amplitudes of N9 and N13-P13 components (but not N20-P20) were significantly smaller in the diabetic group. The peripheral sensory conduction velocity was also decreased in the diabetic group, but there was no significant correlation between peripheral conduction slowing and the onset of CCT prolongation.

CONCLUSIONS: Diabetes affects conductive function in the central as well as peripheral somatosensory pathways. The CCT abnormality does not coincide with lowering of the peripheral sensory conduction. The current results do not favor a hypothesis that a central–peripheral distal axonopathy plays an important role in development of diabetic polyneuropathy.

Key words: Central conduction—Somatosensory evoked potential—Median nerve stimulation—Onset-to-onset measurement—Peak-to-peak measurement—Diabetes mellitus.

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