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Neurology 2000;54:259
© 2000 American Academy of Neurology
Brief Communications

Glioblastoma causing granulocytosis by secretion of granulocyte-colony-stimulating factor

Rogier Q. Hintzen, MD, PhD, Joan Voormolen, MD, Pieter Sonneveld, MD, PhD and Sjoerd G. van Duinen, MD, PhD

From the Departments of Neurology (Dr. Hintzen), Neurosurgery (Drs. Hintzen and Voormolen), Pathology (Dr. van Duinen), Leiden University Medical Center, Leiden; and the Department of Hematology (Dr. Sonneveld), Academic Hospital Rotterdam, Rotterdam, The Netherlands.

Address correspondence and reprint requests to Dr. R.Q. Hintzen, Department of Neurology, Academic Hospital Rotterdam, Postbox 2040, 3000 CA Rotterdam, the Netherlands; e-mail: rhintzen{at}xs4all.nl

We describe a patient with a glioblastoma multiforme with excessive granulocytosis in the peripheral blood. Shown at both protein and mRNA levels, the tumor produced very high levels of granulocyte-colony-stimulating factor (G-CSF). G-CSF is a growth factor that induces the recruitment of granulocytes. The paraneoplastic phenomenon described here partly mimicked a brain abscess. Production of G-CSF by (brain) tumor cells might be related to the granulocytosis common in malignant disease.

Key words: Glioblastoma multiforme—GBM—Granulocyte colony-stimulating factor—G-CSF—Neutrophilia—Leukocytosis




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