| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Neurology, Vol 50, Issue 6 1580-1585, Copyright © 1998 by American Academy of Neurology
ARTICLES |
D Carmelli, GE Swan, T Reed, B Miller, PA Wolf, GP Jarvik and GD Schellenberg
Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA.
OBJECTIVE: To investigate the combined effect of the apolipoprotein E epsilon4 (ApoE*4) allele and midlife cardiovascular risk factors on cognitive decline. METHODS: Data are from the National Heart, Lung, and Blood Institute Twin Study-a longitudinal cardiovascular epidemiologic study of World War II male veteran twins currently in its 27th year of follow-up. Subjects were assessed for cardiovascular risk factors, including BP and glucose levels, at mean ages 48, 58, and 63 years. Participants in the current study are 410 individual twin subjects for whom cognitive function was measured twice, at ages 63 and 73 years. Ten-year change scores in performance on neuropsychological test examinations were adjusted for age, education, baseline score, and incident cardiovascular disease. RESULTS: For the sample as a whole, we observed a significant decline (p < 0.01) in cognitive performance over the 10 years of follow-up. ApoE*4 carriers with midlife hyperglycemia experienced the greatest decline in performance, which was also greater than expected from the separate effects combined. Midlife hypertension and ApoE*4, were each associated with excess decline in performance on tests of psychomotor speed. Their joint effect, however, was not greater than expected from the separate effects combined. CONCLUSIONS: ApoE*4 and midlife cardiovascular risk factors may have a synergistic effect on decline in cognitive function. This effect may be due to greater vascular or degenerative damage among subjects with ApoE*4.
This article has been cited by other articles:
|
|
 |
|
  G. F. Mitchell Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage J Appl Physiol, November 1, 2008; 105(5): 1652 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rentzos, G. P. Paraskevas, E. Kapaki, C. Nikolaou, M. Zoga, A. Tsoutsou, A. Rombos, and D. Vassilopoulos Circulating Interleukin-15 in Dementia Disorders J Neuropsychiatry Clin Neurosci, August 1, 2007; 19(3): 318 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. de Frias, D. Bunce, A. Wahlin, R. Adolfsson, K. Sleegers, M. Cruts, C. Van Broeckhoven, and L.-G. Nilsson Cholesterol and Triglycerides Moderate the Effect of Apolipoprotein E on Memory Functioning in Older Adults J. Gerontol. B. Psychol. Sci. Soc. Sci., March 1, 2007; 62(2): P112 - P118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Xiong, B. L. Plassman, M. J. Helms, and D. C. Steffens Vascular risk factors and cognitive decline among elderly male twins. Neurology, November 14, 2006; 67(9): 1586 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. E. Swan, C. N. Lessov-Schlaggar, D. Carmelli, G. D. Schellenberg, and A. La Rue Apolipoprotein E {epsilon}4 and Change in Cognitive Functioning in Community-Dwelling Older Adults J Geriatr Psychiatry Neurol, December 1, 2005; 18(4): 196 - 201. [Abstract] [PDF]
|
|
|
|
|
|
J. S. Elkins, D. S. Knopman, K. Yaffe, and S. C. Johnston Cognitive function predicts first-time stroke and heart disease Neurology, May 24, 2005; 64(10): 1750 - 1755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Dufouil, F. Richard, N. Fievet, J. F. Dartigues, K. Ritchie, C. Tzourio, P. Amouyel, and A. Alperovitch APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: The Three-City Study Neurology, May 10, 2005; 64(9): 1531 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fujiwara, P. H. M. Chaves, R. Takahashi, H. Amano, H. Yoshida, S. Kumagai, K. Fujita, D. G. Wang, and S. Shinkai Arterial Pulse Wave Velocity as a Marker of Poor Cognitive Function in an Elderly Community-Dwelling Population J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 607 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Lane and M. R. Farlow Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease J. Lipid Res., May 1, 2005; 46(5): 949 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Blair, A. R. Folsom, D. S. Knopman, M. S. Bray, T. H. Mosley, E. Boerwinkle, and for the Atherosclerosis Risk in Communities Study APOE genotype and cognitive decline in a middle-aged cohort Neurology, January 25, 2005; 64(2): 268 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Elkins, E. S. O'Meara, W. T. Longstreth Jr., M. C. Carlson, T. A. Manolio, and S. C. Johnston Stroke risk factors and loss of high cognitive function Neurology, September 14, 2004; 63(5): 793 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Elkins, V. C. Douglas, and S. C. Johnston Alzheimer disease risk and genetic variation in ACE: A meta-analysis Neurology, February 10, 2004; 62(3): 363 - 368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Qiu, B. Winblad, J. Fastbom, and L. Fratiglioni Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD Neurology, September 9, 2003; 61(5): 655 - 660. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kivipelto, E.-L. Helkala, M. P. Laakso, T. Hanninen, M. Hallikainen, K. Alhainen, S. Iivonen, A. Mannermaa, J. Tuomilehto, A. Nissinen, et al. Apolipoprotein E {epsilon}4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease Ann Intern Med, August 6, 2002; 137(3): 149 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Swan and D. Carmelli Evidence for Genetic Mediation of Executive Control: A Study of Aging Male Twins J. Gerontol. B. Psychol. Sci. Soc. Sci., March 1, 2002; 57(2): P133 - 143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. Geschwind, B. L. Miller, C. DeCarli, and D. Carmelli Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness PNAS, February 20, 2002; (2002) 52494999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Peila, L.R. White, H. Petrovich, K. Masaki, G.W. Ross, R.J. Havlik, L.J. Launer, and J. Poirier Joint Effect of the APOE Gene and Midlife Systolic Blood Pressure on Late-Life Cognitive Impairment: The Honolulu-Asia Aging Study Editorial Comment: The Honolulu-Asia Aging Study Stroke, December 1, 2001; 32(12): 2882 - 2889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kivipelto, E.-L. Helkala, T. Hanninen, M. P. Laakso, M. Hallikainen, K. Alhainen, H. Soininen, J. Tuomilehto, and A. Nissinen Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study Neurology, June 26, 2001; 56(12): 1683 - 1689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Newman, J. L. Kirchner, B. Phillips-Bute, V. Gaver, H. Grocott, R. H. Jones, D. B. Mark, J. G. Reves, J. A. Blumenthal, and The Neurological Outcome Research Group and the Ca Longitudinal Assessment of Neurocognitive Function after Coronary-Artery Bypass Surgery N. Engl. J. Med., February 8, 2001; 344(6): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Knopman, L.L. Boland, T. Mosley, G. Howard, D. Liao, M. Szklo, P. McGovern, and A. R. Folsom Cardiovascular risk factors and cognitive decline in middle-aged adults Neurology, January 9, 2001; 56(1): 42 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Bigler, C. M. Lowry, C. V. Anderson, S. C. Johnson, J. Terry, and M. Steed Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype AJNR Am. J. Neuroradiol., November 1, 2000; 21(10): 1857 - 1868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. E. Swan, C. DeCarli, B. L. Miller, T. Reed, P. A. Wolf, and D. Carmelli Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy Neurology, June 13, 2000; 54(11): 2108 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Bennett Diabetes and Change in Cognitive Function Arch Intern Med, January 24, 2000; 160(2): 141 - 143. [Full Text] [PDF]
|
|
|
|
|
|
D. H. Geschwind, B. L. Miller, C. DeCarli, and D. Carmelli Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness PNAS, March 5, 2002; 99(5): 3176 - 3181. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
