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Neurology, Vol 50, Issue 2 565-566, Copyright © 1998 by American Academy of Neurology

ARTICLES

Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer

M Uchuya, A Fleury, F Graus, D Costagliola, R Liblau, H Merle-Beral, I Theodorou and JY Delattre
Department of Neurology, Hopital de la Salpetriere, Paris, France.

We compared the human leukocyte antigen alleles found in a group of 17 patients with small-cell lung cancer (SCLC), paraneoplastic neurologic syndromes (PNS), and high titers of anti-Hu autoantibodies with those in 30 patients with SCLC but no PNS and no anti-Hu antibodies (control group). There was no difference between the two groups, suggesting that specific haplotypes are not required for the development of the "anti- Hu syndrome."


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