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NEUROLOGY 1995;45:S16-S21
© 1995 American Academy of Neurology

Cytokine localization in multiple sclerosis lesions

Correlation with adhesion molecule expression and reactive nitrogen species

Celia F. Brosnan, PhD, Barbara Cannella, PhD, Luca Battistini, MD and Cedric S. Raine, PhD

Department of Pathology, Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461; and Universita `La Sapienza', I Clinica Neurologica, Roma, Italia.
Address correspondence and reprint requests to Dr. C. F. Brosnan, Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461.

The relative levels and cellular distribution of proinflammatory and regulatory cytokines have been examined by immunohistochemistry in multiple sclerosis (MS) lesions of differing activity and compared with CNS tissue from other neurologic diseases with an inflammatory or noninflammatory component.Results show widespread distribution of cytokines in association with both perivascular inflammatory cells and glial cells in all types of inflammatory lesions. Although no obvious pattern of proinflammatory versus regulatory cytokines could be determined in MS lesions, proinflammatory cytokines were rarely noted in normal and noninflammatory conditions, whereas regulatory cytokines were readily detectable in the same diseases. The possible relevance of these cytokine patterns to adhesion molecule expression and the presence of reactive nitrogen species is also addressed.

NEUROLOGY 1995;45(Suppl 6): S16-S21






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