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Neurology, Vol 45, Issue 5 947-950, Copyright © 1995 by American Academy of Neurology
ARTICLES |
MA Pavol, CA Meyers, JL Rexer, AD Valentine, PJ Mattis and M Talpaz
Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-alpha). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-alpha had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN- alpha is highly suggestive of frontal-subcortical brain dysfunction.
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