Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jankovic, J.
Right arrow Articles by Contant, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jankovic, J.
Right arrow Articles by Contant, C.
NEUROLOGY 1995;45:645-648
© 1995 American Academy of Neurology

Tremor and longevity in relatives of patients with Parkinson's disease, essential tremor, and control subjects

J. Jankovic, MD, J. Beach, RN, K. Schwartz, PA and C. Contant, PhD

Article abstract-To study the relation between essential tremor (ET) and Parkinson's disease (PD), we compared the frequency of familial tremor in relatives of patients with PD (N = 391), ET (N = 140), and the combination of ET and PD (N = 125) with the frequency in patients with progressive supranuclear palsy (PSP) (N = 99) and normal age-matched controls (N = 104). Tremor was present in 96 (5.1%) of 1,874 parents and siblings of patients with PD, 152 of 650 (23.4%) relatives of patients with ET, 91 (20.7%) of 439 relatives of patients with ET-PD, 12 of 462 (2.6%) relatives of patients with PSP, and 10 of 448 (2.2%) relatives of normal controls. The high frequency of familial tremor among relatives of patients with PD, and especially those with the ET-PD combination, compared with relatives of patients with PSP or of normal controls suggests that there is an association of PD and familial tremor. Since the most common form of familial tremor is ET, our study provides support for the notion that ET and PD are pathogenetically related. We also found that parents with tremor lived on the average 9.2 years longer than those without tremor. The association of familial tremor with significantly increased longevity suggests that familial tremor confers some anti-aging influence. Alternatively, tremor may be a simple byproduct of the aging process.

NEUROLOGY 1995;45: 645-648




This article has been cited by other articles:


Home page
 NeurologyHome page
E. D. Louis, J. Benito-Leon, R. Ottman, F. Bermejo-Pareja, and On behalf of the Neurological Disorders in Central
A population-based study of mortality in essential tremor
Neurology, November 20, 2007; 69(21): 1982 - 1989.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
H. Deng, W. Le, and J. Jankovic
Genetics of essential tremor
Brain, June 1, 2007; 130(6): 1456 - 1464.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J. Jankovic, K. S Schwartz, and W. Ondo
Re-emergent tremor of Parkinson's disease
J. Neurol. Neurosurg. Psychiatry, November 1, 1999; 67(5): 646 - 650.
[Abstract] [Full Text]

Home page
 Hum Mol GenetHome page
M. Farrer, K. Gwinn-Hardy, M. Hutton, and J. Hardy
The genetics of disorders withsynuclein pathology and parkinsonism
Hum. Mol. Genet., September 1, 1999; 8(10): 1901 - 1905.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
W. W. Wang, M. Khajavi, B. J. Patel, J. Beach, J. Jankovic, and T. Ashizawa
The G209A Mutation in the {alpha}-Synuclein Gene Is Not Detected in Familial Cases of Parkinson Disease in Non-Greek and/or Italian Populations
Arch Neurol, December 1, 1998; 55(12): 1521 - 1523.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1995 by AAN Enterprises, Inc.