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NEUROLOGY 1995;45:2165-2169
© 1995 American Academy of Neurology

Phonologic processing deficits in Alzheimer's disease

N. Biassou, MA, M. Grossman, EdD, MD, K. Onishi, J. Mickanin, E. Hughes, K.M. Robinson, MD and M. D'Esposito, MD

From the Departments of Neurology (Drs. Grossman and D'Esposito, and N. Biassou, K. Onishi, J. Mickanin, and E. Hughes) and Rehabilitation Medicine (Dr. Robinson), University of Pennsylvania School of Medicine, Philadelphia, PA.
Supported in part by the US Public Health Service (AG09399, DC00039, and NS14867).
Presented in part at the Academy of Aphasia, Boston, MA, October 1994.
Received December 12, 1994. Accepted in final form April 8, 1995.
Address correspondence and reprint requests to Dr. Murray Grossman, Cognitive Neurology Section, Department of Neurology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283.

We investigated phonologic production in patients with mild to moderate Alzheimer's disease (AD) on a repetition task.AD patients produced significantly more speech errors than age-matched controls. AD patients' errors, unlike those of controls, resulted in the transformation of real words into pseudowords, occurred disproportionately in word-initial positions, and were not influenced by the phonologic environment. This pattern of errors suggests a lexical phonologic retrieval deficit in AD.

NEUROLOGY 1995;45: 2165-2169




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