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From the Department of Epidemiology and Biostatistics (Drs. de Rijk, Breteler, Ott, Grobbee, and Hofman) and the Department of Neurology, University Hospital Rotterdam (Drs. de Rijk, Graveland, and van der Meche); and the Erasmus Center for Research on Aging (Dr. de Rijk), Erasmus University Medical School, Rotterdam, the Netherlands.
Supported in part by the NESTOR program for geriatric research (Ministry of Health and Ministry of Education), the Netherlands Heart Foundation, the Netherlands Organisation for Scientific Research (NWO), and the Municipality of Rotterdam.
Received December 7, 1994. Accepted in final form March 28, 1995.Address correspondence and reprint requests to Dr. Maarten C. de Rijk, Department of Epidemiology and Biostatistics, Erasmus University Medical School, P.O. Box 1738, 3000 DR, Rotterdam, the Netherlands.
We assessed the prevalence of Parkinson's disease (PD) in a general elderly population in the Netherlands.The study formed part of the Rotterdam Study, a population-based door-to-door study, and included 6,969 persons 55 years of age or older living in a suburb of Rotterdam, the Netherlands. All participants were examined, and those who either had at least one possible cardinal sign of parkinsonism at the neurologic screening, reported that they had PD, or were taking antiparkinsonian drugs were invited for further evaluation. The prevalence of PD in this population was 1.4% (1.2% for men, 1.5% for women). Prevalence increased with age, and prevalence figures were 0.3% for those aged 55 to 64 years, 1.0% for those 65 to 74, 3.1% for those 75 to 84, and 4.3% for those 85 to 94. The corresponding age-specific figures for men were 0.4%, 1.2%, 2.7%, and 3.0%, and for women, 0.2%, 0.8%, 3.4%, and 4.8%. Among 95- to 99-year-old women the prevalence was 5.0%. Twelve percent of the subjects with PD were detected through the screening and had not been diagnosed previously.
NEUROLOGY 1995;45: 2143-2146
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