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NEUROLOGY 1995;45:51-55
© 1995 American Academy of Neurology

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

J. B. Rich, PhD, D. X. Rasmusson, PhD, M. F. Folstein, MD, K. A. Carson, C. Kawas, MD and J. Brandt, PhD

Article abstract-We reviewed the records of 210 patients in the Johns Hopkins Alzheimer's Disease Research Center to evaluate the role of nonsteroidal anti-inflammatory drugs (NSAIDs) on clinical features and progression of the disease. We compared patients taking NSAIDs or aspirin on a daily basis (N = 32) to non-NSAID patients (N = 177) on clinical, cognitive, and psychiatric measures. The NSAID group had a significantly shorter duration of illness at study entry. Even after controlling for this difference, the NSAID group performed better on the Mini-Mental State Examination, Boston Naming Test, and the delayed condition of the Benton Visual Retention Test. Furthermore, analysis of longitudinal changes over 1 year revealed less decline among NSAID patients than among non-NSAID patients on measures of verbal fluency, spatial recognition, and orientation. These findings support other recent studies suggesting that NSAIDs may serve a protective role in Alzheimer's disease.

NEUROLOGY 1995;45: 51-55




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