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NEUROLOGY 1994;44:1278
© 1994 American Academy of Neurology

Clinical and electrophysiologic correlates of elevated anti-GM1 antibody titers

L. J. Kinsella, MD, D. J. Lange, MD, W. Trojaborg, MD, S. A. Sadiq, MD, D. S. Younger, MD and N. Latov, MD, PhD

Department of Neurology, Columbia-Presbyterian Medical Center, New York, NY.

We reviewed the clinical and electrophysiologic features of 36 patients with increased titers of IgM anti-GM1 antibodies. Mildly elevated titers of up to 3,200 were not associated with any particular clinical syndrome or disease. Clinically, 14 of 16 patients with highly elevated titers of 6,400 or higher had progressive weakness with lower motor neuron signs; six had active tendon reflexes and eight had absent reflexes, but none had definite upper motor neuron signs. Electrophysiologic studies showed spontaneous activity in all 14 patients, one or more motor conduction blocks in nine, slowed motor conductions in one, and normal conductions in four patients. None had abnormal sensory conductions. These patients presented with a syndrome that has features of, but is distinct from, both motor neuron disease and demyelinating neuropathy.

Address correspondence and reprint requests to Dr. Norman Latov, Department of Neurology, Columbia-Presbyterian Medical Center, 3-323 Black Building, 650 West 168th Street, New York, NY 10032.

Supported by a Center Grant from the National Institutes of Health (NINDS NS-11766).

Received October 8, 1993. Accepted in final form December 30, 1993.




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