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NEUROLOGY 1992;42:1807
© 1992 American Academy of Neurology

Metabolism of glucurolactone to glucarate in Parkinson's disease

W. C. Roller, MD, PhD, S. D. Rope, BSN, S. J. Huber, PhD, D. C. Blumenthal, PhD and H. J. Blumenthal, PhD

Department of Neurology, University of Kansas Medical Center, Kansas City, KB (Drs. Roller and Huber, and S.D. Rope)
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University, Chicago, IL (Drs Blumenthal and H.J. Blumenthal).

The metabolism of oral glucurolactone to serum D-glucarate by the hepatic cytochrome P450 enzyme system was no different in 20 untreated Parkinson's disease (PD) patients as compared with 20 age-and sex-matched controls. There was no evidence for a deficit in hepatic enzymes in PD.

Address correspondence and reprint requests to Dr. William C. Roller, Department of Neurology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7314.

Received December 5, 1991. Accepted for publication in final form February 4, 1992.






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