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NEUROLOGY 1992;42:1724
© 1992 American Academy of Neurology

Androgen receptor abnormality in X-linked spinal and bulbar muscular atrophy

T. Matsuura, MD, T. Demura, MD, Y. Aimoto, MD, T. Mizuno, MD, F. Moriwaka, MD and K. Tashiro, MD

Departments of Neurology, Hokkaido University School of Medicine, Sapporo, Japan (Drs. Matsuura, Aimoto, Mizuno, Moriwaka, and Tashiro)
Departments of Urology, Hokkaido University School of Medicine, Sapporo, Japan (Dr. Demura).

X-linked spinal and bulbar muscular atrophy (SBMA) is usually associated with feminization and hypogonadism. We were unable to find androgen receptor (AR) in the scrota) skin of three patients with SBMA, and propose that AR abnormality is the cause of the disease.

Address correspondence and reprint requests to Dr. Tohru Matsuura, Department of Neurology, Hokkaido University School of Medicine, Kita-14, Nishi-5, Kita-ku, Sapporo, Hokkaido 060, Japan.

Received October 18, 1991. Accepted for publication in final form February 13, 1992.






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