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NEUROLOGY 1990;40:960
© 1990 American Academy of Neurology

Paraneoplastic motor neuron disease and renal cell carcinoma

Improvement after nephrectomy

B. K. Evans, MD, C. Fagan, MD, T. Arnold, MD, E. J. Dropcho, MD and S. J. Oh, MD

Department of Neurology, University of Alabama at Birmingham, and the Veterans' Administration Medical Center, Birmingham, AL.

A 74-year-old man had a paraneoplastic motor neuron disease mimicking amyotrophic lateral sclerosis. He had an elevated erythrocyte sedimentation rate, other laboratory abnormalities, and a previously undiagnosed renal cell carcinoma. Four months after nephrectomy, his strength had improved and he had no fasciculations. Seven other patients with cancer and motor neuron disease improved or stabilized after tumor treatment. Even though it is rare, paraneoplastic motor neuron disease is important to diagnose because it may be treatable.

Address correspondence and reprint requests to Dr. Bradley K. Evans, Department of Neurology, UAB Station, Birmingham, AL 35294.

Received September 19, 1989. Accepted for publication in final form November 10, 1989.




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