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NEUROLOGY 1990;40:500
© 1990 American Academy of Neurology

Cerebrospinal fluid production is reduced in healthy aging

C. May, MD, J. A. Kaye, MD, J. R. Atack, PhD, M. B. Schapiro, MD, R. P. Friedland, MD and S. I. Rapoport, MD

Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD.

In order to study age-related differences in cerebrospinal fluid (CSF) production in humans, we measured the rate of CSF production in 7 young (age 21 to 36 years) and 7 elderly (age 67 to 84 years) healthy volunteers, using a modified Masserman method. In addition, we evaluated CSF protein gradients by collecting CSF in serial fractions up to the 30th ml and assaying for total protein concentration. The mean rate of CSF production was significantly less in the elderly than in the young subjects. Mean CSF total protein concentrations were higher in the elderly than in the young, and significant rostrocaudal protein gradients with similar slopes were present in both groups. However, there was no correlation between CSF production and CSF total protein concentrations or protein gradient slopes. Age-related reductions in CSF production, together with the ventricular dilatation that occurs with aging, should presumably result in reduced CSF turnover and therefore influence measured concentrations of lumbar CSF constituents.

Address correspondence and reprint requests to Dr. John R. Atack, Neuroscience Research Centre, Merck Sharp and Dohme, Terlings Park, Eastwick Road, Harlow, U.K. CM20 2QR.

Received June 13, 1989. Accepted for publication in final form August 10, 1989.






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