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NEUROLOGY 1990;40:1621
© 1990 American Academy of Neurology

Effect of plasmapheresis on serum and CSF autoantibody levels in CNS paraneoplastic syndromes

F. Graus, MD, J. Abos, MD, J. Roquer, MD, R. Mazzara, MD and A. Pereira, MD

From the Departments of Neurology, and Hemotherapy and Hemostasis, Hospital Clinic i Provincial, and Department of Neurology, Hospital del' Esperanca, Barcelona, Spain.

We compared the effect of plasmapheresis on antineuronal autoantibody titers in the serum and CSF of 3 patients with CNS paraneoplastic syndromes. Plasmapheresis reduced the serum autoantibody titer to 20% of the initial levels in the 3 patients, but the CSF autoantibody titer decreased only in the patient with severe damage of the blood-brain barrier.

Address correspondence and reprint requests to Dr. Francese Graus, Department of Neurology, Hospital Clinic i Provincial, Villarroell70,08036 Barcelona, Spain.

Supported in part by grant FIS 89/0058, Madrid, Spaibt.

Received December 1,1989. Accepted for publication in final form March 22, 1990.




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