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NEUROLOGY 1989;39:522
© 1989 American Academy of Neurology

Cerebrovascular complications of mucinous cancers

Lonnie Amico, MD, Louis R. Caplan, MD and Chinnamma Thomas, MD

Department of Neurology, Michael Raese Hospital, University of Chicago. Chicago, IL (Drs. Amico and Caplan)
Department of Pathology, Michael Raese Hospital, University of Chicago. Chicago, IL (Dr. Thomas).

Six patienta with mucinous cancer (2 colonic, 2 pancreatic, and 2 pulmonary origin) had necropsy evidence of thrombosis of large and small systemic, extra cranial, and intracranial arteries and veins, and multiple cerebral infarcts and small hemorrhages. On microscopic examination, we found small infarcts and hemorrhages within the brain and muslin within vessels, macrophages, and in areas of infarction. The clinical picture included strokes and encephalopathy. Mucin-producing cancers can be associated with a coagulopathy that causes extensive occlusive vascular disease.

Address correspondence and reprint requests to Dr. Chaplin, Department of Neurology, New England Medical Center. 750 Washington Street, Boston. MA 02111.

Received July 1,1988. Accepted for publication in final form October 4, 1988.




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