| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Neurology, University of Massachusetts Medical Center, Worcester, MA.
The extent and location of neuronal losses necessary or sufficient to produce dementia in patients with Alzheimer's Disease (AD) is unknown. To approach this question, we studied synaptic terminals in postmortem brain tissue utilizing immunohistochemical techniques. We used antibodies against two proteins found in synaptic terminals—synapsin I and synaptophysin—as synaptic markers in the hippocampal complexes of eight patients with autopsy-proven AD and eight nondemented control subjects. Quantitative microscopy measured the regional density of synaptic staining. All AD patients showed a striking decrease in synaptic staining in the outer half of the molecular layer of the dentate gyrus compared with control brains, where the density of synaptic terminals was uniform throughout. In an additional patient with progressive degenerative dementia but without plaques or tangles on neuropathologic examination, similar depletion of synaptic staining was seen in the dentate gyrus. Quantitative densitometric analyses confirmed the focal decrease in synaptic staining in the outer half of the molecular layer in demented patients. We also found a slight increase in synaptic staining in the inner half of this layer.
Address correspondence and reprint requests to Dr. Hamos, Department of Neurology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655.
Supported in part by grants from the Massachusetts Department of Public Health, the Massachusetts Alzheimer's Disease Research Center (NIA grant P50 AG05134), the Sterling Morton Research Fund, and the Stanley and Harriet Friedman Research Fund.
Presented in part at the fortieth annual meeting of the American Academy of Neurology, Cincinnati, OH, April 1988.
Received July 22, 1988. Accepted for publication in final form September 29, 1988.
This article has been cited by other articles:
|
|
 |
|
  G. J. Revuelta, A. Rosso, and C. F. Lippa Neuritic Pathology as a Correlate of Synaptic Loss in Dementia With Lewy Bodies American Journal of Alzheimer's Disease and Other Dementias, March 1, 2008; 23(1): 97 - 102. [Abstract] [PDF]
|
|
|
|
 |
|
 J. H. Chin, L. Ma, D. MacTavish, and J. H. Jhamandas Amyloid {beta} Protein Modulates Glutamate-Mediated Neurotransmission in the Rat Basal Forebrain: Involvement of Presynaptic Neuronal Nicotinic Acetylcholine and Metabotropic Glutamate Receptors J. Neurosci., August 29, 2007; 27(35): 9262 - 9269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Bandyopadhyay, G. Li, H. Yin, and J. Kuret Tau Aggregation and Toxicity in a Cell Culture Model of Tauopathy J. Biol. Chem., June 1, 2007; 282(22): 16454 - 16464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Haleem, C. F. Lippa, T. W. Smith, H. Kowa, Jianlin Wu, and T. Iwatsubo Presenilin-1 C410Y Alzheimer Disease Plaques Contain Synaptic Proteins American Journal of Alzheimer's Disease and Other Dementias, April 1, 2007; 22(2): 137 - 144. [Abstract] [PDF]
|
|
|
|
|
|
C. F. Lippa An Individualized Approach to Treatment for Alzheimer's Disease, Pick's Disease, and Other Dementias. American Journal of Alzheimer's Disease and Other Dementias, October 1, 2006; 21(5): 354 - 359. [Abstract] [PDF]
|
|
|
|
|
|
C. F. Lippa Synaptophysin immunoreactivity in Pick's disease: Comparison with Alzheimer's disease and dementia with Lewy bodies American Journal of Alzheimer's Disease and Other Dementias, November 1, 2004; 19(6): 341 - 344. [Abstract] [PDF]
|
|
|
|
 |
|
 H.-g. Lee, P. I. Moreira, X. Zhu, M. A. Smith, and G. Perry Staying Connected: Synapses in Alzheimer Disease Am. J. Pathol., November 1, 2004; 165(5): 1461 - 1464. [Full Text] [PDF]
|
|
|
|
 |
|
 J-C Mwanza, L K Nyamabo, T Tylleskar, and G T Plant Neuro-ophthalmological disorders in HIV infected subjects with neurological manifestations Br. J. Ophthalmol., November 1, 2004; 88(11): 1455 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Coleman, H. Federoff, and R. Kurlan A focus on the synapse for neuroprotection in Alzheimer disease and other dementias Neurology, October 12, 2004; 63(7): 1155 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Davis, D. G. Stewart, J. I. Friedman, M. Buchsbaum, P. D. Harvey, P. R. Hof, J. Buxbaum, and V. Haroutunian White Matter Changes in Schizophrenia: Evidence for Myelin-Related Dysfunction Arch Gen Psychiatry, May 1, 2003; 60(5): 443 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mehring, J. C.Y. Lin, D. Wilson, and C. F. Lippa Frontotemporal dementia with ubiquitinated inclusions: A case study of the regional distribution of hippocampal pathology American Journal of Alzheimer's Disease and Other Dementias, September 1, 2000; 15(5): 277 - 283. [Abstract] [PDF]
|
|
|
|
 |
|
 J. E. Donahue, T. M. Berzin, M. S. Rafii, D. J. Glass, G. D. Yancopoulos, J. R. Fallon, and E. G. Stopa Agrin in Alzheimer's disease: Altered solubility and abnormal distribution within microvasculature and brain parenchyma PNAS, May 25, 1999; 96(11): 6468 - 6472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Kuller, L. Shemanski, T. Manolio, M. Haan, L. Fried, N. Bryan, G. L. Burke, R. Tracy, and R. Bhadelia Relationship Between ApoE, MRI Findings, and Cognitive Function in the Cardiovascular Health Study Stroke, February 1, 1998; 29(2): 388 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Oster-Granite, D. L. McPhie, J. Greenan, and R. L. Neve Age-Dependent Neuronal and Synaptic Degeneration in Mice Transgenic for the C Terminus of the Amyloid Precursor Protein J. Neurosci., November 1, 1996; 16(21): 6732 - 6741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gomez-Isla, J. L. Price, D. W. McKeel Jr., J. C. Morris, J. H. Growdon, and B. T. Hyman Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer''s Disease J. Neurosci., July 15, 1996; 16(14): 4491 - 4500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Kajkowski, C. F. Lo, X. Ning, S. Walker, H. J. Sofia, W. Wang, W. Edris, P. Chanda, E. Wagner, S. Vile, et al. beta -Amyloid Peptide-induced Apoptosis Regulated by a Novel Protein Containing a G Protein Activation Module J. Biol. Chem., May 25, 2001; 276(22): 18748 - 18756. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
