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The familial nature of multiple sclerosis

Age-corrected empiric recurrence risks for children and siblings of patients

From the Department of Medical Genetics (Drs. Sadovnick and Baird) and the Multiple Sclerosis Clinic (Dr. Sadovnick), Health Sciences Centre Hospital, University of British Columbia, Vancouver, BC, Canada.

Increasingly, MS patients ask neurologists about the risk that their close relatives will also develop MS. We calculated age-adjusted empiric recurrence risks from data on 815 index cases and over 3,000 of their siblings and children. In general, the risk for these relatives to develop MS is 3 to 5%, which is 30 to 50 times the 0.1% rate for the general population.

Address correspondence and reprint requests to Dr. Sadovnick, Department of Medical Genetics, University of British Columbia, 6174 University Boulevard, Vancouver, BC V6T 1W5, Canada.

Supported by the Multiple Sclerosis Society of Canada.

Received May 11, 1987. Accepted for publication in final form October 2, 1987.

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