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NEUROLOGY 1988;38:946
© 1988 American Academy of Neurology

Corticospinal axons persist in cervical and high thoracic regions 10 weeks after a T-9 spinal cord transection

J. Ned Pruitt, II, BS, Earl R. Feringa, MD and Russell L. McBride, PhD

From the Medical College of Georgia and The Veterans Administration Medical Center, Augusta, GA.

Ten weeks after complete spinal cord transection at T-9, there was a decrease in the volume of the rat corticospinal tract but no loss in the number of axons contained in the cervical (C-2) or high thoracic (T-l) corticospinal tract. The mean area of the myelinated axon profile decreased in spinal cord-transected rats, with fewer axons found in the largest size groups and more in the smaller size groups. The survival of corticospinal axons in the cervical and thoracic cord 10 weeks after cord transection at T-9 indicates that the corticospinal neurons survive at least 10 weeks after cord transection. The fate of axotomized neurons after longer survival times remains to be determined.

Address correspondence and reprint requests to Mr. Pruitt, c/o Earl R. Feringa, MD, Neurology (127), VA Medical Center, Augusta, GA 30910.

Supported by a student research fellowship of the Medical College of Georgia awarded to Mr. Pruitt, and the Veterans Administration Medical Research Service.

Presented in part at the thirty-ninth annual meeting of the American Academy of Neurology, New York, NY, April 1987.

Received September 1, 1987. Accepted for publication in final form October 23, 1987.






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