HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bailey, R. O. Articles by Bishop, M. B. Search for Related Content PubMed PubMed Citation Articles by Bailey, R. O. Articles by Bishop, M. B.

Sensory motor neuropathy associated with AIDS

From the Neurology (Drs. Bailey and Venkatesh), Medical (Infectious Disease) (Dr. Baltch), and Pathology (Drs. Singh and Bishop) Services of the Veterans Administration Medical Center, and the Departments of Neurology (Drs. Bailey and Venkatesh) and Medicine (Dr. Baltch), Albany Medical College of Union University, Albany, NY.

Clinical, laboratory, and pathologic observations in six patients with sensory motor peripheral neuropathy associated with the acquired immunodeficiency syndrome (AIDS) are presented. Blood and urine testing failed to reveal other causes for peripheral neuropathy. Distinctive CSF findings included elevated human immunodeficiency virus-specific indices. Peripheral nerve pathology confirmed the results of electrodiagnostic studies and revealed axonal loss and demyelination. Epineurial and endoneurial mononuclear infiltrates were present in three patients, and in one with early neuropathy, retro viral-like particles were present in peripheral nerve axoplasm. The findings indicate that in some patients with AIDS, neuropathy may be the direct result of a viral insult, although the causes are likely multifactorial.

Address correspondence and reprint requests to Dr. Bailey, Neurology Section, Riverside Medical Clinic, 3660 Arlington Avenue, Riverside, CA 92506.

Supported by the Veterans Administration.

Received June 11, 1987. Accepted for publication in final form October 9, 1987.

This article has been cited by other articles:

				M. Tagliati, J. Grinnell, J. Godbold, and D. M. Simpson Peripheral Nerve Function in HIV Infection: Clinical, Electrophysiologic, and Laboratory Findings Arch Neurol, January 1, 1999; 56(1): 84 - 89. [Abstract] [Full Text] [PDF]

				L. Cui, L. Locatelli, M.-Y. Xie, and J.-P. Sommadossi Effect of Nucleoside Analogs on Neurite Regeneration and Mitochondrial DNA Synthesis in PC-12 Cells J. Pharmacol. Exp. Ther., March 1, 1997; 280(3): 1228 - 1234. [Abstract] [Full Text]