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Peptide specificities of myelin basic protein-reactive human T-cell clones

From the Multiple Sclerosis Research Center (Dr. Richert and Ms. Reuben-Burnside), Department of Neurology, Georgetown University Medical Center, Washington, DC, and the Laboratory of Cerebral Metabolism (Mrs. Deibler and Dr. Kies), National Institute of Mental Health, Bethesda, MD.

Forty myelin basic protein (BP) -reactive T-cell clones were isolated from a patient with multiple sclerosis and used to identify human T-cell recognition sites on the BP molecule. At least three sites have been identified: one in the N-terminal half of the molecule (residues 1–97), one in the C-terminal (residues 98–170), and one which spans residues 97–98. The clones exhibited a marked preference for the C-terminal half of the molecule. No cross-reactivity with measles virus was detected. These clones will be useful for both the further delineation of the human T-cell recognition sites on BP and the generation of anticlonotypic monoclonal antibodies.

Address correspondence and reprint requests to Dr. John R. Richert, Multiple Sclerosis Research Center, Department of Neurology, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington, DC 20007.

Supported by NIH contract No. NO1-NS-5-2391. Dr. Richert is the recipient of an NINCDS Teacher Investigator Award.

Presented in part at the thirty-ninth annual meeting of the American Academy of Neurology, New York, NY, April 1987.

Received June 30, 1987. Accepted for publication in final form August 26, 1987.

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