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Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles

Psychiatry Research Laboratories, Ramsey Clinic/St. Paul-Ramsey Medical Center, St. Paul, MN.

Ganglioside monoclonal antibody (A2B5) labels Alzheimer's neurofibrillary tangles both in isolated neurofibrillary tangle-bearing nerve cells and in partially purified preparations of tangle fibers. Antibody staining was preab-sorbed by preincubation of antibody with neuronal ganglioside preparations. These results suggest that Alzheimer's neurofibrillary tangles have a ganglioside associated with them.

Address correspondence and reprint requests to Dr. Frey, Psychiatry Research Laboratories, Ramsey Clinic/%. Paul-Ramsey Medical Center, 640 Jackson Street, St. Paul, MN 55101.

Supported by St. Paul-Ramsey Foundation grant #8399, as well as funds from the State of Minnesota, the 3M Foundation, the Alice M. O'Brien Foundation, and the Robert L. Fry Fund for Alzheimer's Research.

Received May 19, 1986. Accepted for publication in final form September 5, 1986.

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